The 10–20 system or International 10–20 system is an internationally recognized method to describe and apply the location of scalp electrodes in the context of an EEG exam, polysomnograph sleep study, or voluntary lab research. This method was developed to maintain standardized testing methods ensuring that a subject's study outcomes (clinical or research) could be compiled, reproduced, and effectively analyzed and compared using the scientific method. The system is based on the relationship between the location of an electrode and the underlying area of the brain, specifically the cerebral cortex.

During sleep and wake cycles, the brain produces different, objectively recognized and distinguishable electrical patterns, which can be detected by electrodes on the skin. (These patterns might vary, and can be affected by multiple extrinsic factors, i.e. age, prescription drugs, somatic diagnoses, hx of neurologic insults/injury/trauma, and substance abuse)

The "10" and "20" refer to the fact that the actual distances between adjacent electrodes are either 10% or 20% of the total front–back or right–left distance of the skull. For example, a measurement is taken across the top of the head, from the nasion to inion. Most other common measurements ('landmarking methods') start at one ear and end at the other, normally over the top of the head. Specific anatomical locations of the ear used include the tragus, the auricle and the mastoid.